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Xiaflex is covered by all major US health insurance plans. Precertification is necessary and typically takes 1-2 weeks. All associated costs including doctor visits are typically covered by health plans.
HCPCS Code: J0775 Injection, collagenase, clostridium histolyticum, 0.01 mg: 0.01 mg = 1 billable unit.
Alternatives to Xiaflex include observation without treatment, penile modeling with vacuum devices or traction devices, penile plication surgery, plaque incision and grafting surgery, and penile prosthesis surgery.
XIAFLEX, supplied as a lyophilized powder, must be reconstituted with the provided diluent prior to use. The dose of XIAFLEX is 0.58 mg per injection into a palpable cord with a contracture of a metacarpophalangeal (MP) joint or a proximal interphalangeal (PIP) joint.
Due to the risks of serious injury, Xiaflex is only available through a drug safety program when used for Peyronies disease. This is called the Xiaflex Risk Evaluation and Mitigation Strategy (REMS) program.
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Pain, swelling, bruising, bleeding, redness, itching at or around the injection site may occur. Swollen, painful areas in the elbow and underarm (swollen lymph nodes) may also occur when this medication is injected in the hand. If any of these effects last or get worse, tell your doctor promptly.
The withdrawal was at the request of the marketing authorisation holder, Swedish Orphan Biovitrum AB (publ), which notified the European Commission of its decision to permanently discontinue the marketing of the product for commercial reasons.
PRODUCT DISCONTINUATION FROM 28 JUNE 2019 It has provided a non-surgical option for patients with Dupuytrens Contracture and Peyronies Disease.

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