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What are the prognostic indicators in multiple myeloma?
Traditional prognostic factors in MM measure plasma cell proliferation (plasma cell labeling index, Ki-67), plasma cell mass (clinical stage, plasmacytosis), or the status of the patient (hemoglobin, calcium, creatinine, albumin).
What are myeloma defining events?
Myeloma-defining events include the presence of one or more CRAB features, or one or more biomarkers of malignancy. The three biomarkers included in the definition of MM are associated with an approximately 80% risk of progression to symptomatic end-organ damage in two or more independent studies.
What percentage of myeloma patients are high risk?
Fifteen to 20% of cases of MM are considered high risk, which is characterized by reduced survival as a result of tumor biology, some form of frailty, or suboptimal or no response to therapy. Identification of different risk factors for aggressive disease is crucial to managing this difficult-to-treat population.
What is considered high risk multiple myeloma?
The high-risk features include patient-specific factors such as old age, poor performance status and comorbidities; clinical features such as primary plasma cell leukemia and extramedullary disease; disease-specific biologic features such as deletion 17p, t(4;14) and high-risk gene expression profiling signatures.
What is standard risk myeloma?
In general, myeloma that does not have any of these cytogenetic abnormalities is referred to as standard-risk disease. Although risk can be defined and characterized in several ways, approximately 15% of patients with myeloma are considered to have high-risk disease at the time they are diagnosed.
Instructions for Florida Supreme Court Approved Family Law Form 12.950(d), Supplemental Petition to Permit Relocation with Child(ren). Instructions for Florida Supreme Court Approved Family Law Form 12.950(d)
Instructions for Florida Supreme Court Approved Family Law Form 12.950(d), Supplemental Petition to Permit Relocation with Child(ren). Instructions for Florida Supreme Court Approved Family Law Form 12.950(d)
What is usually the first early symptom of multiple myeloma?
Low blood counts Anemia: A reduced number of red blood cells that can cause weakness, a reduced ability to exercise, shortness of breath, and dizziness.
What are the odds of getting multiple myeloma?
Multiple myeloma is a relatively uncommon cancer. In the United States, the lifetime risk of getting multiple myeloma is 1 in 132 (0.76%). The American Cancer Societys estimates for multiple myeloma in the United States for 2022 are: About 34,470 new cases will be diagnosed (19,100 in men and 15,370 in women).
What is the life expectancy of high risk multiple myeloma?
Multiple myeloma is an uncommon cancer of the blood. The median length of survival after diagnosis with multiple myeloma is 62 months for Stage I, 44 months for Stage II, and 29 months for Stage III.
How do people cope with multiple myeloma?
Here are some tips for coping with multiple myeloma: Understand your diagnosis. Communicate openly with your treatment team. Find help to manage your symptoms. Report any side effects. Learn to relax your mind and body. Seek extra support.
What is the main cause of multiple myeloma?
Scientists still do not know exactly what causes most cases of multiple myeloma. However, they have made progress in understanding how certain changes in DNA can make plasma cells become cancerous.
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