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The new 2/20/20 clinical risk stratification model incorporates 3 factors (serum M-protein 2 g/dL, involved to uninvolved FLC ratio 20, and BMPC infiltration 20%) to stratify patients with SMM diagnosed ing to the IMWG 2014 criteria into low-risk, intermediate-risk, and high-risk groups (0 factors, 1 factor,
What is the multiple cause of death analysis?
Irrespective of the methodologic approach, multiple cause analysis complements the single underlying cause approach, uses useful information that is usually ignored, and offers an additional perspective of the causes that contribute to death.
What is the gold standard for diagnosing multiple myeloma?
A bone marrow biopsy is usually needed to confirm multiple myeloma. A needle is used to take a small sample of bone marrow (where all the blood cells are made) from one of your bones, usually the pelvis. A small sample of bone may also be removed.
What is a major criterion for the diagnosis of multiple myeloma?
The diagnosis of MM requires 10% or more clonal plasma cells on bone marrow examination or a biopsy-proven plasmacytoma plus the presence of one or more myeloma-defining events. 10 Myeloma-defining events in- clude the presence of one or more CRAB features, or one or more biomarkers of malignancy.
What are the diagnostic criteria for multiple myeloma?
Original CRAB Criteria for the Diagnosis of Multiple Myeloma Hypercalcemia: serum calcium 0.25 mmol/L (1mg/dL) higher than the upper limit of normal or 2.75 mmol/L (11mg/dL) Renal insufficiency: creatinine clearance 177 micro mol/L (2mg/dL)
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What is the risk stratification for multiple myeloma?
Risk stratification: The presence of del(17p), t(4;14), t(14;16), t(14;20), gain 1q, del 1p, or p53 mutation is considered high-risk multiple myeloma. Presence of any two high risk factors is considered double-hit myeloma; three or more high risk factors is triple-hit myeloma.
What are the diagnostic criteria for multiple myeloma in 2020?
Diagnosis: The diagnosis requires 10% clonal bone marrow plasma cells or a biopsy proven plasmacytoma plus evidence of one or more multiple myeloma defining events (MDE) namely CRAB (hypercalcemia, renal failure, anemia, or lytic bone lesions) features felt related to the plasma cell disorder, bone marrow clonal
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Multiple myeloma: 2020 update on diagnosis, risk
by SV Rajkumar 2020 Cited by 861 The diagnosis requires 10% clonal bone marrow plasma cells or a biopsy proven plasmacytoma plus evidence of one or more multiple myeloma defining events (MDE).
You should submit your Fall 2020 Multiple Position Report online as soon as possible, but no later than August 25, 2020. All necessary approvals must be
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