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How does mRNA-4157 work?

About mRNA-4157 (V940) Upon administration into the body, the algorithmically derived and RNA-encoded neoantigen sequences are endogenously translated and undergo natural cellular antigen processing and presentation, a key step in adaptive immunity.

What are the side effects of the V940 vaccine?

The most common adverse events attributed to mRNA-4157 (V940) in combination with KEYTRUDA were fatigue (60.6%), injection site pain (56.7%), and chills (49.0%). The majority of the adverse events attributed to mRNA-4157 (V940) were Grade 1-2, with fatigue being the most common Grade 3 event and no Grade 4-5 events.

How does mRNA-4157 V940 work?

mRNA-4157/V940 is designed to stimulate an immune response by generating specific T cell responses based on the unique mutational signature of a patients tumor. KEYTRUDA is an immunotherapy that works by increasing the ability of the bodys immune system to help detect and fight tumor cells.

How does mRNA vaccine work explain?

After vaccination, the mRNA will enter the muscle cells. Once inside, they use the cells machinery to produce a harmless piece of what is called the spike protein. The spike protein is found on the surface of the virus that causes COVID-19.

What is the V940 vaccine?

mRNA-4157/V940 is an mRNA based cancer vaccine. When administered, it will produce one of several dozen possible abnormal proteins commonly found in cancerous tissues. The production of those proteins is intended to invoke an immune response.

Is mRNA-4157 safe?

Safety, tolerability, and immunogenicity were assessed. All patients experienced 1 treatment-emergent adverse event; there were no grade 4/5 adverse events or dose-limiting toxicities. mRNA-4157 alone induced consistent de novo and strengthened preexisting T-cell responses to targeted neoantigens.

Is KEYTRUDA discontinued?

Fatal adverse reactions occurred in 8% of patients who received KEYTRUDA including infection (2.3%) and thromboembolism (1.3%). KEYTRUDA was permanently discontinued due to adverse reactions in 15% of patients.

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