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Most often, all that is required is a blood sample. However, samples of urine, saliva, sputum, feces, semen, and other bodily fluids and tissues also can be tested. For some samples, they can be obtained as the body naturally eliminates them.
\u201cCLIA-exempt\u201d formally refers to a laboratory (not a test system) and means a laboratory that has been licensed or approved by a state where CMS has determined that the state has enacted laws relating to laboratory requirements that are equal to or more stringent than CLIA requirements, and the State licensure program ...
Under New York State Public Health Law (Article 5, Title V, Section 574) and regulations (Part 58- 1.10 (g) of 10NYCRR), laboratories performing testing for any specimens collected in the State of New York must hold a New York State clinical laboratory permit or have test request approval for specific tests.
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The U.S. Centers for Medicare and Medicaid Services (CMS) has announced that New York State-licensed laboratories are exempt from the requirements of the Clinical Laboratory Improvement Amendments of 1988 (CLIA) for a period of six years as long as they possess a valid permit under the New York State Public Health Law.
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In October 1993, Washington became the first state to have its clinical laboratory licensure program judged by the Federal Health and Human Services Centers for Medicare and Medicaid Services (CMS) as equivalent to CLIA and was granted an exemption.
In order to be "licensed under the provisions of law relating to the healing arts", the healthcare practitioner must be licensed in the state of California as a physician and surgeon, or licensed as a healthcare provider with a scope of practice that authorizes ordering clinical laboratory tests.
CLIA defines a clinical laboratory as any facility which performs laboratory testing on materials derived from the human body, for the purpose of providing information for the diagnosis, treatment or prevention of disease or the assessment of a health condition.
The U.S. Centers for Medicare and Medicaid Services (CMS) has announced that New York State-licensed laboratories are exempt from the requirements of the Clinical Laboratory Improvement Amendments of 1988 (CLIA) for a period of six years as long as they possess a valid permit under the New York State Public Health Law.
Current Regulation: CLIA established three categories of tests: waived tests, moderate complexity tests, and high complexity tests.

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