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These differences is the high sequence - idi harvard

These differences is the high sequence - idi harvard 2025

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The document discusses the structural biology of calpains and GGA proteins, focusing on their roles in calcium-mediated activation and cargo sorting in cellular transport. It highlights the sequence diversity in calpain's dIII domain affecting its Ca2+-sensitivity and the mechanism by which GGA proteins recognize sorting signals for transmembrane proteins like mannose-6-phosphate receptors. The findings provide insights into the specificity of protein interactions involved in membrane trafficking, with implications for understanding viral fusion mechanisms, particularly in Dengue virus.

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