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Postmortem Biochemical Estimations in Cases of Fatal Hypothermia

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The document presents a study on postmortem biochemical estimations in cases of fatal hypothermia, focusing on the levels of catecholamines (adrenaline and noradrenaline) and volatile substances (such as acetone and ethanol). It analyzes four cases of fatal hypothermia compared to 12 control cases with varying durations of agony. The findings indicate a significant predominance of noradrenaline in hypothermia cases, especially those with longer agony, while adrenaline levels were higher in cases with shorter agony. The study suggests that combined analysis of catecholamines and volatile substances can aid in diagnosing fatal hypothermia, although variations and overlapping results pose challenges.

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What are necropsy findings in fatal hypothermia cases?

The best diagnostic signs seem to be purple skin and oedema in face and ears, stomach erosions, degenerative foci in myocardium and high concentration of catecholamines in the urine.

What are the biochemical markers of hypothermia?

The rise in cortisol levels might reflect the biological stress response to cold, and cortisol has been suggested as a marker for cold exposure23. Another docHub mechanism during hypothermia induced stress is vasoconstriction, where peripheral blood vessels constrict to minimize heat loss.

What are the post mortem findings of hypothermia?

In general, autopsy findings of hypothermia are as follows: gastric mucosal hemorrhagic spots (Wischnewski spots), differences in the color of the left and right heart blood, soft blood clots, chicken fat clots in the heart and large blood vessels, lungs without edema, and a large amount of urine retention [9].

What is postmortem lividity in hypothermia?

Livor mortis, also known as postmortem hypostasis or postmortem lividity, is a passive process of blood accumulating within the blood vessels in the dependent parts of the body as a result of gravity, causing a discoloration of the skin that varies from pink to dark purplish.