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THE MOLECULAR EPIDEMIOLOGY OF HIV-1 IN 2025

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The document presents a thesis by Owaisuddin Ahmed on the development and evaluation of openXdata Mobile Charts, a prototype software designed to generate instant graphic reports for mobile devices in the field of international health. The software automates chart creation from a database, making it accessible via a password-protected web application tailored for mobile phones. A usability survey was conducted with 12 participants, yielding high satisfaction scores (mean SUS score of 88.1 out of 100) and indicating strong user-friendliness. The findings suggest that the software could significantly aid researchers in visual data reporting tasks.

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What is the molecular epidemiology of HIV-1 in African countries a comprehensive overview?

In Africa, it is estimated that more than 20 million people are living with HIV/Acquired Immunodeficiency Syndrome (AIDS) and that more than 730,000 new HIV-1 infections still occur each year, likely due to low access to testing.

What is the molecular mechanism of HIV-1 entry?

During HIV-1 entry into target cells, binding of the virus to host receptors, CD4 and CCR5/CXCR4, triggers serial conformational changes in the envelope glycoprotein (Env) trimer that result in the fusion of the viral and cell membranes.

Which HIV type is common in Africa?

HIV-1, which traces its origins from the area around the Congo Basin in Africa, is the most prevalent strain globally. It is responsible for about 95% of all HIV infections. HIV-2 is mostly found in west Africa, though it also affects a small number of people in Europe, India and the United States.

What is the molecular structure of HIV?

HIV-1 virions contain two copies of a single-stranded RNA genome within a conical capsid surrounded by a plasma membrane of host-cell origin containing viral envelope proteins.

What is the molecular epidemiology of a virus?

Molecular epidemiology of viral infections Molecular epidemiology is the integration of epidemiology, the study of the distribution and risk factors of disease, and molecular biology, the study of biological diversity and processes at the molecular level.

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What is the molecular biology of HIV virus?

The HIV-1 genome is approximately 9,200 to 9,600 nucleotides and is flanked at both ends by long terminal repeat (LTR) sequences. There are 9 protein-coding viral genes encoded by overlapping reading frames: gag, pol, vif, vpr, tat, rev, vpu, env, and nef.

THE MOLECULAR EPIDEMIOLOGY OF HIV-1 IN 2025

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What is the molecular epidemiology of HIV-1 in African countries a comprehensive overview?

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