DEA-254 CSOS Certificate Application Registrant List 2025

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Every healthcare provider who administers, prescribes, or dispenses any controlled substance must be registered with the U.S. Drug Enforcement Administration (DEA). As a resident working within your program, you are covered under the registration of your training hospital or institution.
A Controlled Dangerous Substance (CDS) License is a certification that allows individuals or businesses to legally handle and distribute controlled substances, as regulated by state and federal laws.
Answer: A CSOS Certificate enables DEA Registrants and Power of Attorneys to conduct electronic ordering of controlled substances by providing identification, authentication, and non-repudiation through the use of digital signature technology.
Did you know that the United States currently has over 2 million Drug Enforcement Administration (DEA) registrants engaging in activities with controlled substances?
The DEA, Office of Diversion, E- commerce Section, operates the Controlled Substance Ordering System (CSOS) whose purpose is to issue and revoke digital signatures to DEA Registrants (manufactures, distributors, and pharmacies who order controlled substances) to digitally sign electronic orders for controlled
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People also ask

A DEA Registrant is the individual who signed, or is authorized to sign, the most recent application for DEA registration renewal. Registrants are required to approve requests for CSOS certificates for their subordinates (Coordinators and Power of Attorneys).
How long after I apply for a CSOS Certificate will I receive it? CSOS Certificate activation notices can be expected approximately eight weeks from the date the application package is sent to DEA. Incomplete, inaccurate, or invalid application packages will take longer to process and may be denied and returned by DEA.
A CSOS certificate will expire on the date on which the DEA registration on which the certificate is based expires. (b) The Certification Authority will notify each CSOS certificate holder 45 days in advance of the expiration of the certificate holders CSOS digital certificate.

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