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Schedule V drugs are generally used for antidiarrheal, antitussive, and analgesic purposes. Some examples of Schedule V drugs are: cough preparations with less than 200 milligrams of codeine or per 100 milliliters (Robitussin AC), Lomotil, Motofen, Lyrica, Parepectolin.
A CSOS Power of Attorney (POA) is any individual with the authority to sign controlled substance orders for a DEA Registrant. The CSOS POA applicant must have their request approved by the CSOS Coordinator for the DEA Registration number(s) being applied for.
Applicants cannot have sold, distributed, manufactured, or transported any illegal drug or controlled substance without legal authorization. Applicants cannot have used any illegal drug, other than marijuana, within the seven (7) years preceding the date of the application for employment.
This provision of the regulations is often referred to as the five percent rule. This regulation further provides that, if a practitioner has reason to believe that the amount he or she will distribute to other practitioners will exceed this five percent threshold, the practitioner must register as a distributor.
The DEA, Office of Diversion, E- commerce Section, operates the Controlled Substance Ordering System (CSOS) whose purpose is to issue and revoke digital signatures to DEA Registrants (manufactures, distributors, and pharmacies who order controlled substances) to digitally sign electronic orders for controlled
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CSOS Coordinators Coordinators can approve Power of Attorney requests for enrollment, renewal, or revocation. If Coordinators are not enrolled, the Power of Attorney requests will be assigned to the Registrant.
Schedule V drugs are the least likely of the controlled substances to be misused. They result in very limited physical or psychological dependence. Examples include cough medicines with codeine, antidiarrheal medications that contain atropine/diphenoxylate, pregabalin, and ezogabine.
The Controlled Substances Act (CSA) places all substances which were in some manner regulated under existing federal law into one of five schedules. This placement is based upon the substances medical use, potential for abuse, and safety or dependence liability.

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