Rationale and Application Of Fatty Acid Oxidation Inhibitors in - sf-planning 2025

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Because of their structural diversity, fatty acids are extensively used as feedstocks for food applications and the oleochemicals industry for the manufacture of soaps, detergents, lubricants, coatings, and cosmetics among other specialty products.
Fatty acid synthesis is a metabolic pathway that synthesizes fatty acids. Under lipogenic conditions, excess glucose in the cell is first converted to pyruvate via glycolysis in the cytoplasm. Pyruvate enters the mitochondria and is converted to acetyl-CoA and transported as citrate from mitochondria into cytoplasm.
We also found that inhibition of fatty acid oxidation decreases nicotinamide adenine dinucleotide phosphate (NADPH) levels and the reduced glutathione (GSH) content and elevates intracellular reactive oxygen species. These results suggest that modulation of fatty acid oxidation controls the NADPH level.
Fatty acid synthase (FAS) catalyzes the de novo synthesis of fatty acids. In the liver, FAS has long been categorized as a housekeeping protein, producing for storage of energy when nutrients are present in excess.
Fatty acid oxidation inhibitors are a new potent class of drugs used in treatment of stable angina pectoris and an addition in treatment of chronic heart failure.
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Biomedical Significance of Fatty Acid Synthesis Most mammals use glucose as their main substrate for lipogenesis, but ruminants use acetate as their main dietary source of fuel.
Fatty acid oxidation is the main source of energy for many tissues including heart and skeletal muscle and is critical during times of fasting or physiologic stress. When the bodys glycogen stores are depleted, long-chain fatty acids are mobilized from adipose tissue and taken up by liver and muscle cells.
FAS is a key enzymatic complex in FA synthesis from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated FAs155 and it is expressed at high levels in liver and adipose tissue, but at low levels in other tissues.

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