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What is the function of the pit1?

Pit-1 activates transcription of the growth hormone and prolactin genes and is necessary for the control of the beta-TSH gene transcription. The various mutations have different effects on the DNA binding and transactivating properties of Pit-1.

What is the full form of POU1F1 gene?

POU1F1 - Pituitary-specific positive transcription factor 1 - Homo sapiens (Human) | UniProtKB | UniProt.

What does the PITX1 gene do?

The PITX1 gene provides instructions for making a protein that plays a critical role in development of the lower limbs. The PITX1 protein is found primarily in the developing legs and feet.

What is prop paired like Homeobox 1 PROP1?

PROP1 (PROP Paired-Like Homeobox 1) is a Protein Coding gene. Diseases associated with PROP1 include Pituitary Hormone Deficiency, Combined, 2 and Combined Pituitary Hormone Deficiencies, Genetic Forms.

What is the mutation in PITX1?

mutations in PITX1 can cause a broad spectrum of isolated lower-limb malformations including clubfoot, deficiency of long bones, and mirror-image polydactyly. These studies identify PITX1 as a new ERalpha transcriptional target.

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