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The Canadian Immunization Guide (1) advises that MMR and varicella vaccinations should be given at the same time or separated by at least four weeks. These alternative schedules elicit equivalent immune responses to all four antigens (2).
Both vaccines contain live, attenuated measles, mumps, and rubella virus. MMRV also contains live, attenuated varicella-zoster virus. The lyophilized live MMR vaccine and MMRV vaccine should be reconstituted and administered as recommended by the manufacturer1,2.
Each 0.5-mL dose of ProQuad is administered subcutaneously. The first dose is usually administered at 12 to 15 months of age but may be given anytime through 12 years of age. If a second dose of measles, mumps, rubella, and varicella vaccine is needed, ProQuad may be used.
Simultaneous Administration of Different Vaccines vaccine should not be administered simultaneously to persons with functional or anatomic asplenia or HIV. Menactra brand meningococcal conjugate vaccine is thought to interfere with the antibody response to Prevnar 13.
This immunization is usually given at 12 months of age, and between the ages of 4 to 6 years. Typically no further immunizations are required.

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As their child's healthcare provider, you remain parents' most trusted source of information about vaccines. For the first dose of measles, mumps, rubella, and varicella vaccines given at ages 12-47 months, either MMR and varicella vaccines or MMRV vaccine can be used.
MMRV vaccine may be given to children 12 months through 12 years of age, usually: First dose at age 12 through 15 months. Second dose at age 4 through 6 years.
Varicella vaccine may be given at the same time as other vaccines. Also, a child between 12 months and 12 years of age might receive varicella vaccine together with MMR (measles, mumps, and rubella) vaccine in a single shot, known as MMRV.
Legend Vaccine19-26 years\u226565 yearsTetanus, diphtheria, pertussis (Tdap or Td)1 dose Tdap, then Td or Tdap booster every 10 yearsMeasles, mumps, rubella (MMR)1 or 2 doses depending on indication (if born in 1957 or later)Varicella (VAR)2 doses (if born in 1980 or later)2 doses12 more rows
MMRV should not be given as the first measles, mumps and rubella (MMR) containing vaccine in children less than four years of age as it can increase the risk of febrile seizures.

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