The spontaneous resolution of Primary congenital Glaucoma - Healio 2025

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The prognosis for untreated PCG is almost always buphthalmos and blindness, except in the rare case of spontaneously arrested PCG. When PCG is being managed, the prognosis seems to depend on the age of onset, which depends on the severity of the angle anomaly.
Glaucoma is not a fatal condition. A 2021 study of 5,385 people, including 138 participants with glaucoma at baseline, found no evidence that glaucoma increased mortality risk or caused a shorter life expectancy. Researchers found that in people with glaucoma, higher mortality rates were only due to older age.
Prior studies have reported surgical success in primary congenital glaucoma as an IOP
Of the 776 patients diagnosed with primary congenital glaucoma in the study population, 27 died (Table 4). The mean period from diagnosis of primary congenital glaucoma to death was 21.59 29.31 months. In total, 70.4% (n = 19) of these patients died within 3 years of birth, while 29.6% (n = 8) died thereafter.
Congenital glaucoma is an important cause of blindness in very young children, but vision can be preserved if it is identified and treated as early as possible.
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It damages their vision and can even lead to blindness if it goes untreated. Children should have surgery as soon as possible to correct the defect. Surgery can stop the progress of the disease and may recover some or all of their vision loss.

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