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CD3 is a common T-lymphocyte antigen, present on the surface of all T-lymphocytes. CD4 is an antigen present on the surface of T-helper-lymphocytes (T-helper cells), monocytes, and some white blood cells. activated granules. CD8 is an antigen present on the surface of cytotoxic and inhibitory T cells.
A cluster with 20 CD3-positive cells is a candidate indicator for BM involvement in PTCL. Peripheral T-cell lymphomas, not otherwise specified (PTCLs) represent approximately 10% of all non-Hodgkin lymphomas [1].
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3 chain, a CD3 chain, and two CD3 chains.
The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells, cortical thymocytes, and dendritic cells. The CD8 molecule is a marker for cytotoxic T cell population.
The percentage of CD3+ T cells, often referred to as mature T cells, is a crucial component of the immune system and plays a central role in defending the body against infections and other foreign invaders.
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As mentioned above, the CD3 protein complex is an important T cell marker for the classification of malignant lymphomas and leukemias (T cell neoplasms). CD3 can also be used for the identification of T cells in coeliac disease (Leon et al. 2011), lymphocytic colitis and collagenous colitis (Mosnier et al.

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