(Polidocanol Injection): Side Effects, Interactions 2025

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Check with your doctor right away if you have difficulty with speaking, slow speech, inability to speak, inability to move the arms, legs, or facial muscles, chest pain or discomfort, pain or discomfort in the arms, jaw, back, or neck, pain, redness, or swelling in the arm or leg, trouble breathing, or dizziness or
Varithena Side Effects Injection site pain and bruising. Allergic reactions (rare) Nerve irritation (rare) Blood clots (very rare)
The most common side effects seen with Varithena are leg pain or discomfort, injection site bruising or pain, and potentially serious blood clots in the leg veins. These are not all the possible side effects of Varithena. Tell your healthcare provider about any side effect that bothers you or that does not go away.
Possible risks of sclerotherapy include: Irritation and swelling, called inflammation. You might have mild swelling, warmth and discomfort around the site where the needle went into the skin. Taking a pain reliever you can get without a prescription might help.
Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
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There are no known drug interactions with VARITHENA. Few published case reports with use of polidocanol-containing products, including VARITHENA, in pregnant women have not identified any drug-associated risk for major birth defects, miscarriage, or adverse maternal or fetal outcomes.
First 7 days: Do NOT participate in strenuous exercise (like weightlifting or squatting). First 14 days: Wear the compression stockings day and night. First 28 days: Walk one hour each day, which can be divided into 10 to 20-minute intervals. No sitting for long stretches of time, including car or plane trips.
Asclera is available as a 0.5% and 1% solution in 2 mL glass ampules. Asclera is contraindicated for patients with known allergy (anaphylaxis) to polidocanol and patients with acute thromboembolic diseases.

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