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Which of the following things can pass the blood brain barrier?

Small polar molecules, such as glucose, amino acids, organic anions and cations, and nucleosides, can cross the blood-brain barrier by carrier-mediated transport. These solute carriers may be specific to one molecule or multi-specific to several molecules.

What passes through the blood-brain barrier?

Some examples of drugs and substances that can get through the BBB (either on their own or with transport help) include: Alcohol. Anesthetics. Antidepressant medications. Anxiolytics (antianxiety medications). Antipsychotic medications. Medications that treat seizures or epilepsy. Caffeine.

What is transported through the blood-brain barrier?

The BBB is referred to as a carrier because of its ability to transport the necessary nutritional molecules like vitamins, minerals, glucose, lipid-soluble molecules, and gases such as carbon dioxide and oxygen present in the blood to the brain as well as helping the elimination of toxins/metabolites [3].

What can move freely through the blood brain barrier?

The bloodbrain barrier restricts the passage of pathogens, the diffusion of solutes in the blood, and large or hydrophilic molecules into the cerebrospinal fluid, while allowing the diffusion of hydrophobic molecules (O2, CO2, hormones) and small non-polar molecules.

What forms the blood-brain barrier?

[1] The BBB is composed of endothelial cells (ECs), pericytes (PCs), capillary basement membrane, and astrocyte end-feet, all of which aim to shield the brain from toxic substances, filter harmful compounds from the brain to the bloodstream, and supply brain tissue with nutrients.

What can diffuse across BBB?

Gases, such as CO2, O2, N2O and Xe, and volatile anesthetics diffuse rapidly into the brain. As a consequence, the rate at which their concentration in the brain comes into equilibrium with the plasma is limited primarily by the cerebral blood flow rate.

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