Dehydroascorbic acid, a blood brain barrier transportable form of 2025

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Ascorbic acid was not able to cross the blood-brain barrier in our studies. In contrast, the oxidized form of vitamin C, dehydroascorbic acid (oxidized ascorbic acid), readily entered the brain and was retained in the brain tissue in the form of ascorbic acid.
Taking vitamin C can increase your absorption of aluminum from medications containing aluminum, such as phosphate binders. This can be harmful for people with kidney problems. Chemotherapy. There is concern that use of antioxidants, such as vitamin C, during chemotherapy might reduce the effect of chemotherapy drugs.
Although the antioxidant ascorbic acid (AA) or vitamin C does not the bloodbrain barrier (BBB), its oxidized form, dehydroascorbic acid (DHA), enters the brain by means of facilitative transport.
Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters.
Transport pathways across blood brain barrier. Under physiological conditions, substances may cross the BBB by passive diffusion, carrier mediated transport, receptor mediated transport, and adsorptive transcytosis.
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Ascorbic acid affects synaptic neurotransmission by preventing neurotransmitter binding to receptors [10], by modulating their release and reuptake [11], and also acting as a cofactor in neurotransmitter synthesis [12].
Since entry of glucose into the brain is critical, mechanisms for glucose transport across the bloodbrain barrier have been studied particularly well [11]. Stereospecific, but insulin-independent, GLUT-1 glucose transporters are highly enriched in brain capillary endothelial cells (Fig.

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