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The most common causes for neuropathic pain can be divided into four main categories: disease, injury, infection, and loss of limb.
Neuropathic pain refers to pain that originates from pathology of the nervous system. Diabetes, infection (herpes zoster),nerve compression, nerve trauma, channelopathies, and autoimmune disease are examples of diseases that maycause neuropathic pain.
Neuropathic pain, defined as pain arising as a direct consequence of a lesion or disease affecting the somatosensory system [1], is considered a maladaptive response of the nervous system to damage [2,3] leading to increased excitability of the pain processing circuitry, and symptomatically expressed as allodynia (
Central neuropathic pain can result from any type of injury to the central nervous system (CNS) including vascular (ischemic or hemorrhagic), infectious (abscess, encephalitis, myelitis), demyelinating, traumatic (brain or spinal cord), or neoplastic disorders.
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