Neuropathic pain: a pathway for care developed by the 2025

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Neuropathy is a disturbance of function or a change in one or several nerves. About 30% of neuropathy cases occur due to diabetes, but hundreds of other diseases like shingles, HIV/AIDS and alcohol use disorder can cause it, too.
Neuropathic pain refers to pain that originates from pathology of the nervous system. Diabetes, infection ( zoster),nerve compression, nerve trauma, channelopathies, and autoimmune disease are examples of diseases that maycause neuropathic pain.
Figure 7-1 illustrates the major components of the brain systems involved in processing pain-related information. There are four major processes: transduction, transmission, modulation, and perception.
Neuropathic pain reflects both peripheral and central sensitization mechanisms. Abnormal signals arise not only from injured axons but also from the intact nociceptors that share the innervation territory of the injured nerve.
The associated pain is typically secondary to injury to small, unmyelinated C-fiber nerve axons. The pathogenesis of neuropathic pain commonly involves the loss of peripheral axons and inappropriate peripheral and central adaptation of neuronal signaling secondary to this loss.

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Peripheral neuropathic pain results from lesions to the peripheral nervous system (PNS) caused by mechanical trauma, metabolic diseases, neurotoxic chemicals, infection, or tumor invasion and involves multiple pathophysiological changes both within the PNS and in the CNS (Dworkin et al.
Central mechanisms of neuropathic pain involve a number of major pathways. Nociception is ordinarily transduced by a polysynaptic pathway through the spinal cord, and up the spinothalamic tract to the thalamus and then the cortex.

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