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A contamination control strategy (CCS) is a system that considers all the integral elements of pharmaceutical product manufacturing. A CCS should cover: Microbial contamination. Cleaning and disinfection. Sterility assurance.
Microbiological control is a regulatory requirement and one that can be defined as the continued interaction of science and applied technology with products, processes, materials, equipment, and personnel entering the manufacturing areas. In the ISO 14644-1, control of microbial contamination is addressed.
Infection control and workplace cleanliness Infection control procedures relating to cleanliness in the workplace include: regularly washing the floors, bathrooms and surfaces( such as tables and bench tops) with hot water and detergent. periodically washing the walls and ceilings.
Contamination control measures need to be designed into each part of the production process and should include the use of contamination controls such as cleaning, decontamination, sterilization and transfer methods for primary packaging materials, consumables and intermediate product that reduce the contamination risks
Microbiological and viral contamination control (Microbio Contam Ctrl) refers to the non-intended or accidental introduction of infectious material like bacteria, yeast, mold, fungi, virus, prions, protozoa, or their toxins and by-products.
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The contamination control strategy needs to address the elements of the process design that protect the product from microbial, pyrogen, chemical, non-viable particulate, and cross product contamination. Gases used in aseptic processes need to be filtered with a sterilizing grade filter at the point of use.
The aim of all contamination control activities is to permanently ensure a sufficient level of cleanliness in controlled environments. This is accomplished by maintaining, reducing, or eradicating viable and non-viable contamination for either sanitary purposes or in order to maintain an efficient rate of production.

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