Whole Exome Sequencing Recommendation Form - Cigna 2025

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Whole Genome Sequencing Overview/Scope WGS can identify or confirm the genetic etiology of a disorder in patients (procedure code 81425). When needed for additional diagnostic insight, comparator genomes can be used from a relative such as parents or siblings(procedure code 81426).
Whole-exome sequencing (WES) analyzes protein-coding sections of the genome, while whole-genome sequencing (WGS) analyzes both coding and noncoding regions.
Not all health insurance companies will pay for the cost of the test. All WES tests will be discussed with your insurance company before testing. You will be responsible for all co-pays and deductibles.
ExomeSeq is a test that looks at most of the genes. This test may be useful for patients whose medical and family histories suggest a genetic cause for their signs and symptoms. Most patients who have whole exome sequencing (WES) have had other genetic testing that did not find a genetic cause of their condition.
620022: Whole Exome Sequencing - TRIO (Proband) | Labcorp.
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WES will be authorized for 3 months when the criteria for initial approval are met. Bill CPT code as appropriate (81415, 81416, 81417).

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