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Push half of the naloxone (1mL/1cc) into each nostril. The naloxone vial contains 2mL, so you are giving one half in one nostril and one half in the other nostril. Single-step nasal spray: Peel back tab with circle to open, insert tip into either nostril and administer full dose.
Naloxone should be kept at the bedside and may be administered intravenously as 0.4-mg bolus for severe respiratory depression and in increments of 0.04 mg for mild to moderate depression. An infusion of naloxone may be required with long-acting opioids, because naloxone has a relatively short half-life.
Injecting into the muscle of the upper thigh or upper arm (see below) with a syringe is also a very common way to administer naloxone. Many naloxone kits come with a syringe and a vial (seen in photo below) or a pre-filled cartridge of naloxone.
Therefore, it is critical to obtain medical intervention as soon as possible after administering/receiving naloxone. The medication can be given by intranasal spray (into the nose), intramuscular (into the muscle), subcutaneous (under the skin), or intravenous injection.
Naloxone is able to be administered through several different methods. This includes an autoinjector, a syringe, a nasal spray, and an atomizer.
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There are two forms of naloxone that anyone can use without medical training or authorization: prefilled nasal spray and injectable.

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