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The recommended dose of VIVITROL is 380 mg delivered intramuscularly every 4 weeks or once a month. The injection should be administered by a healthcare professional as an intramuscular (IM) gluteal injection, alternating buttocks for each subsequent injection, using the carton components provided (2 and 16.1).
The recommended dose of VIVITROL is 380 mg delivered intramuscularly (deep) as a gluteal injection every 4 weeks or once a month, alternating buttocks for each subsequent injection, using the carton components provided [see How Supplied/Storage and Handling (16)].
After IM injection, the naltrexone plasma concentration time profile is characterized by a transient initial peak, which occurs approximately 2 hours after injection, followed by a second peak observed approximately 2 - 3 days later.
The patient first needs detoxification from opioids before starting naltrexone; the patient must be opioid-free (including tramadol) for at least 7 to 10 days. Advise patients not to self-administer opioids while receiving naltrexone therapy.
Anyone who receives a VIVITROL injection must not use any type of opioid (must be opioid-free) including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, buprenorphine or methadone, for at least 7 to 14 days before starting VIVITROL.
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Under the direction of their healthcare provider, patients can receive their Vivitrol injections at one of our pharmacy locations in a private, comfortable injection suite, administered by a trained pharmacist, as a part of our pharmacist-managed Vivitrol program.
VIVITROL must be prepared and administered by a healthcare provider. VIVITROL must ONLY be administered as a deep intramuscular gluteal injection.
The naltrexone readiness form is used to verify the patients medical history, drug use history, lab information, physical exam findings, and other pertinent information to check patient readiness.

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