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Gut microbiota dysbiosis not only modulates the immune responses of the gastrointestinal (GI) tract but also impacts the immunity of distal organs, such as the lung, further affecting lung health and respiratory diseases.
Probiotics and Lung Infection Administration of probiotics has been associated with lower incidence of ventilator-associated pneumonia,25 reduced respiratory infections in healthy and hospitalized children,26, 27 and reduced duration of common cold infection.
Immune regulation works in both directions, affecting both the lung and gut microbiomes. A healthy gut microbiome composition can contribute to a higher resistance to airway infections and their symptoms, as has been demonstrated for common cold infections.
Recent research has established the link between the lungs and the gutthe gut-lung axis -and the gut microbiome is a major component. The gut microbiome is likely perturbed in COPD, contributing to chronic inflammation.
The gut microbiota and the lungs are connected in two directions. Simply put, immune cells located in the gut wall can leave the gut and travel through the lymphatic system to other locations around the body including the lungs and, inversely, respiratory infections can alter gut microbiota composition and functions.
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When your body doesnt have enough good bacteria, bad bacteria can thrive. The following can be signs of a gut bacteria imbalance: Autoimmune problems, such as thyroid issues, rheumatoid arthritis and type 1 diabetes. Digestive issues, such as irritable bowel syndrome, constipation, diarrhea, heartburn or bloating.
Group B Streptococcus is the most common cause of bacterial infection in the newborn. Infection in many cases causes persistent pulmonary hypertension, which impairs gas exchange in the lung.
Some common underlying causes of pulmonary hypertension include high blood pressure in the lungs arteries due to some types of congenital heart disease, docHub tissue disease, coronary artery disease, high blood pressure, liver disease (cirrhosis), blood clots to the lungs, and chronic lung diseases like emphysema
PAH is a common complication of autoimmune diseases, such as systemic sclerosis (SSc), mixed docHub tissue disease and systemic lupus erythematosus 11, 12. SSc is characterised by excessive collagen deposition in the dermis and internal organs, vascular hyper-reactivity and obliterative microvascular phenomena 13.
Nowadays, gut microbiota deviations are linked with many diseases including obesity, type 2 diabetes, hepatic steatosis, intestinal bowel diseases (IBDs) and several types of cancer. Thus, suggesting that various pathways involved in immunity, energy, lipid and glucose metabolism are affected.

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