TUBERCULOSIS PRESCRIPTION / MEDICATION REQUEST FORM 2025

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Instructions: This form is to be used by participating physicians and providers to obtain coverage for a formulary drug requiring prior authorization (PA), a non-formulary drug for which there is no suitable alternative available, or any overrides of pharmacy management procedures such as step therapy, quantity limit
Rifampin (RIF), Isoniazid (INH), Pyrazinamide (PZA), and. Ethambutol (EMB)
For initial empiric treatment of TB, start patients on a 4-drug regimen: isoniazid, rifampin, pyrazinamide, and ethambutol. Once the TB isolate is known to be fully susceptible, ethambutol can be discontinued.
Table 5.1Drugs used in the treatment of tuberculosis DrugAdult dose mg/kg (range); [maximum dose] Group 1: first-line oral drugs Ethionamide (Eto) 1520 mg/kg [1000 mg] Prothionamide (Pto) 1520 mg/kg [1000 mg] Terizidone (Trd) 1520 mg/kg [900 mg]25 more rows
4R = 4 months of rifampicin; 9H = 9 months of isoniazid; CI = confidence interval. Active TB was diagnosed in one participant of the 4R arm (rate: 0.09/100 person-years, equivalent to 0.21 over the 28-month period) and four in the 9H arm (rate: 0.36/100 person-years, equivalent to 0.83 over the 28-month period).
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Rifampin, isoniazid, pyrazinamide, and ethambutol are first-line antitubercular medications, which are FDA-approved and indicated for the treatment of Mycobacterium tuberculosis infections.
The 4-month TB treatment regimen (high-dose daily rifapentine with moxifloxacin, isoniazid, and pyrazinamide) and 6-month RIPE (rifapentine, isoniazid, pyrazinamide, and ethambutol) regimen have unique considerations. The below table compares the recommended evaluation and testing considerations for the two regimens.

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