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Is breast cancer a germline mutation?

Approximately 7% of breast and 13% of ovarian cancers are estimated to be due primarily to germline mutations in the BRCA1/2 genes.

What type of mutation is Lynch syndrome?

Lynch syndrome is due to inherited changes (mutations) in genes that affect DNA mismatch repair, a process that fixes mistakes made when DNA is copied. These genes (MLHL, MSH2, MSH6, PMS2, and EPCAM) normally protect you from getting certain cancers, but some mutations in these genes prevent them from working properly.

What is li-fraumeni syndrome?

Li-Fraumeni syndrome (LFS) is an inherited familial predisposition to a wide range of certain, often rare, cancers. This is due to a change (mutation) in a tumor suppressor gene known as TP53.

What type of mutation is germline?

A gene change in a bodys reproductive cell (egg or sperm) that becomes incorporated into the DNA of every cell in the body of the offspring. Germline mutations are passed on from parents to offspring.

How common is Li-Fraumeni?

Frequency. Li-Fraumeni syndrome is thought to occur in 1 in 5,000 to 1 in 20,000 people worldwide.

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