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Hyaluronan injections are used to keep joints moving and reduce pain, especially when other treatments haven't worked. Hyaluronic acid is naturally found inside many joints in your body in the synovial fluid.
Pain relief is not immediate, and usually begins around the fourth week after the initial injection. Duration of relief periods may vary from 2 months up to 6 months. The most effective period is usually between weeks 5 and 13.
Avoid activities such as jogging, soccer, tennis, heavy lifting, or standing on your feet for a long time. Temporary pain or swelling in the knee joint may occur after receiving hyaluronic acid injection. Call your doctor if the pain or swelling in the knee persists or becomes worse after receiving this medicine.
Intra-articular corticosteroid injection has been used for decades to treat patients with knee and hip OA, especially individuals who cannot tolerate the side-effects of long-term pharmaceutical therapy with acetaminophen and nonsteroidal anti-inflammatory drugs.
At 48 months, 82% (N = 144) of the study population treated with intra-articular hyaluronic acid avoided THR. In the group of 93 patients considered candidates for THR only 17 had undergone THR, with survival results of 82% at 24 months. At 48 months, this percentage reduced to 66% in this group (29).

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Hyaluronan injections have very few side effects. However, some people may have pain, stiffness or swelling in their joint after the injection. There's also a small risk of infection. If you notice any symptoms after the injection, tell the person treating you.
Do not strain your knee joint for two days after receiving this medicine. Avoid activities such as jogging, soccer, tennis, heavy lifting, or standing on your feet for a long time. Temporary pain or swelling in the knee joint may occur after receiving hyaluronic acid injection.
You can have hyaluronic acid injections every six months or so. Many patients find that the injections provide enough relief that they can delay or even avoid knee replacement surgery.

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