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Pain is a significant public health concern, with more Americans affected by pain than by diabetes, heart disease, and cancer combined. The National Center for Health Statistics reports that 1 in 4 Americans have experienced pain lasting 24 hours, contributing to healthcare costs exceeding $635 billion annually due to medical treatment and lost productivity. Between 1999 and 2010, the sale of opioid pain relievers surged over fourfold, with enough prescribed in 2010 to medicate every adult in the U.S. continuously for a month. Despite this, 40% of patients report inadequate pain management. The reasons for the use of urine drug testing by physicians are discussed further in the context of pain management.