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A tetramer (/ˈtɛtrəmər/) (tetra-, four + -mer, parts) is an oligomer formed from four monomers or subunits.
MHC tetramers are produced by mixing enzymatically biotinylated MHC fusions to a BirA substrate peptide (BSP) (Schatz, 1993) with fluorescent conjugates of streptavidin or avidin (Altman et al., 1996); the MHC molecules used for tetramer preparations are homogeneous with respect to the peptide ligand that occupies the
Location. The NIH Tetramer Facility is part of the Emory Vaccine Center located in the Emory National Primate Research Center (ENPRC) at Emory University in Atlanta, GA.

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Purpose: The NIH Tetramer Core Facility (TCF) at Emory University was established in 1999 for the production and distribution to the research community of major histocompatibility complex (MHC) tetramers and related reagents for the detection of T cell responses to viruses, bacteria, parasites, tumors, auto-antigens,

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