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Assumption of Shipping Costs account number or by making arrangements for prepaid shipments. No shipments will be made until Recipient s proposed shipping arrangements are accepted by the NIH Tetramer Facility. A Biographical Sketch from a recent NIH grant proposal may be submitted instead. The NIH Tetramer Facility will not bill requesters for shipping charges you MUST provide an account number so that your shipping company can bill you. The intent of these conditions is to protect both the ri ...

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What is tetramer and its structure?

Tetramer: A structure composed of four identical smaller units, or four very similar smaller units. The units may be associated by covalent bonds or by noncovalent forces. This tetrapeptide is Gly-Gly-Gly-Gly, a tetramer composed of four identical amino acid residues (each is a glycine).

How does a tetramer work?

Tetramer analysis is a technique that uses MHC molecules to detect T-cells that recognize peptides or antigens from infected cells or cancerous cells. A tetramer has four MHC molecules attached to a streptavidin-coated bead. T-cells that recognize the peptide in the four MHC molecules will bind to the tetramer.

What are tetramer CD8 T cells?

Tetramer stains usually analyze cytotoxic T lymphocyte (CTL) populations. CTLs are also called CD8+ T-cells, because they have CD8 co-receptors that bind to MHC class I molecules.

What do tetramers do?

The tetramers used in the assay are made up of four major histocompatibility complex (MHC) molecules, which are found on the surface of most cells in the body.... Tetramer assaySynonymsTetramer stainPurposeuses tetrameric proteins to detect and quantify T cells

What are MHC tetramers used for?

MHC tetramers are used for the analyses of T cell immunity, as these reagents allow accurate enumeration and efficient immunomagnetic sorting of antigen-specific T cells, regardless of the T cell's functional capacity.

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