US Patent # 5,744,155. Bioadhesive emulsion preparations for ... 2025

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  2. Review the title and abstract sections carefully. These provide a summary of the bioadhesive emulsion preparations and their applications.
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Intermolecular bonding. It is considered as the main mechanism of bioadhesion. According to the adsorption theory, the adhesion between adhesive and adherent is due to the surface forces acting between the chemical structures at the two surfaces when they are pressed together.
Based on their properties, the specific bioadhesive polymers (e.g., lectins, and fimbrins) have the ability to adhere to specific chemical structures within the biological molecules while the nonspecific bioadhesive polymers (e.g., polyacrylic acid [PAA] and cyanoacrylates) have the ability to bind with both the cell
Shellac is an early example of a bioadhesive put to practical use. Additional examples now exist, with others in development: Commodity wood adhesive based on a bacterial exopolysaccharide. USB PRF/Soy 2000, a commodity wood adhesive that is 50% soy hydrolysate and excels at finger-jointing green lumber.
For drug delivery purposes, the term bioadhesion implies attachment of a drug carrier system to a specified biological location. The biological surface can be epithelial tissue or the mucus coat on the surface of a tissue. If adhesive attachment is to a mucus coat, the phenomenon is referred to as mucoadhesion.
Adhesion can be defined as the process of two surfaces fixing to one another. The adhesion of a synthetic or natural polymer to a biological substrate is known as bioadhesion. The word bioadhesion refers to the attachment of a drug carrier system to a particular biological site for drug delivery.

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 Bioadhesion may be defined as the state in which two materials, at least one of which is biological in nature, are held together for extended periods of time by interfacial forces.  The rationale being that the formulation will be held on a biological surface for localized drug delivery.
A drug delivery system consists of the intravenous, intramuscular, oral, or enteral administration of a pharmacologically active substance for a targeted response [1].

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