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The principal risks of HRT are thromboembolic disease (venous thromboembolism (VTE) and pulmonary embolism), stroke, breast and endometrial cancer, and gallbladder disease. Large studies, including the WHI and the Million Women Study (MWS), raised concerns and controversy over the use of HRT [18, 26].
Standard recommendations \u2014 The standard recommendation for duration of menopausal hormone therapy (MHT) use has been five years or less (and not beyond age 60 years) [66]. However, for most women, hot flashes persist for as long as 10 to 20 years after the final menstrual period.
If you are healthy, most experts agree that HRT is safe to use at the lowest dose that helps for the shortest time needed. If you're 59 or older, or have been on hormones for 5 years, you should talk to your doctor about quitting.
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Stroke, blood clots, and heart attack. Women who took either combined hormone therapy or estrogen alone had an increased risk of stroke, blood clots, and heart attack (1, 2). For women in both groups, however, this risk returned to normal levels after they stopped taking the medication (3, 4).
New research suggests that HRT is generally linked to only small increased risks. Different types of HRT were linked to different risks of breast cancer. The details of this study should help guide discussions between doctors and women considering HRT. Symptoms of the menopause can be severe in many women.
Questions \u201cAre hormones right for me? Why? What are the benefits? What are the serious risks and common side effects? How long should I use hormone therapy? What is the lowest dose that will work for me? Are there any non-hormone medicines that I can take?\u201d
There are two ways of taking it: cyclical combined HRT is best if you have menopausal symptoms and still have periods. This involves having a gap between taking progestogen for a period of time. Continuous combined HRT is recommended if you are post-menopausal and have not had a period for a year.
Hormone replacement therapy may increase the risk of heart attack, stroke, breast cancer, and blood clots in the lungs and legs.

hormone replacement therapy questionnaire