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Subcutaneous Immunoglobulin (SCIg) infusions are given by slowly injecting purified immunoglobulin into fatty tissue just underneath the skin. SCIg: Requires frequent administration (ranging from 1-3 times per week to once a fortnight) by patients or carers at home.
IVIG is typically given every three-four weeks at a dose determined by the prescriber. Infusions can be given in various settings including an inpatient or outpatient infusion suite, physician office, or in the home. IVIG is administered by a healthcare professional, and the procedure is scheduled in advance.
Hizentra is a subcutaneous infusion therapy, which means IV access is not involved. Instead, you can self-administer by infusing just under the skin, not into your veins, after receiving training from your doctor.
The most common side effects in the clinical trials for Hizentra include redness, swelling, itching, and/or bruising at the infusion site; headache; chest, joint or back pain; diarrhea; tiredness; cough; rash; itching; fever, nausea, and vomiting. These are not the only side effects possible.
Subcutaneous immune globulin (SCIG) is made from plasma, the liquid part of blood, which comes from blood donors. SCIG contains antibodies, which can help fight illness/sickness. There are several brands of SCIG in Canada. SCIG is an alternative to intravenous immune globulin (IVIG).
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Several brands of IVIg can be given subcutaneously, but there are a couple of products made specifically for subcutaneous administration. These are 20% in concentration, in contrast to most IVIg products which are 10%.
Recommended infusion sites include the abdomen, thighs, upper arms, and side of upper leg/hip. Your healthcare professional will teach you how to properly administer Hizentra.
Administer directly via the bottle provided by blood bank. Do not remove IVIg from the bottle and attempt to administer via a syringe driver. IVIg does not contain any antimicrobial preservative, therefore each bottle of IVIg must be administered within 6 hours from spiking the bottle.
Most infusion medications are not painful to receive. The placement of the IV catheter may feel painful to some people.
Self administration of high dose IVIg at home, prescribed according to a daily functional strength diary kept by the patient, is a feasible and effective technique. It is well liked by patients, and is associated with excellent control of syptoms in chronic motor neuropathies.

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