MED-12-018 2025

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Oncogene, Tumor Suppressor MED12 plays a role in the genesis of benign tumors such as uterine leiomyoma and fibroadenoma and is altered in a variety of estrogen-dependent tumors.
Normal Function. The MED12 gene provides instructions for making a protein called mediator complex subunit 12. As its name suggests, this protein forms one part (subunit) of the mediator complex, which is a group of about 25 proteins that work together to regulate gene activity.
MED12 Regulates Smooth Muscle Cell Functions and Participates in the Development of Aortic Dissection. Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids.
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