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Ixodes scapularis INFESTATIONS - Oklahoma State University bb - digital library okstate

Ixodes scapularis INFESTATIONS - Oklahoma State University bb - digital library okstate 2025

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The document is a doctoral thesis by Consuelo Almazán-Garcia focused on the identification and characterization of protective antigens for controlling Ixodes scapularis infestations. It discusses the economic importance of ticks, their life cycle, and their role as vectors for various diseases. The research employs expression library immunization (ELI) to identify cDNAs that induce immune responses against tick infestations. Key findings include the identification of three protective antigens (4F8, 4D8, and 4E6) that were shown to inhibit tick infestations in mouse models. The study emphasizes the potential for developing effective vaccines against tick-borne diseases through these identified antigens.

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What diseases are carried by the tick species Ixodes scapularis?

In the United States, the blacklegged tick, Ixodes scapularis, is a vector of seven human pathogens, including those causing Lyme disease, anaplasmosis, babesiosis, Borrelia miyamotoi disease, Powassan virus disease, and ehrlichiosis associated with Ehrlichia muris eauclarensis.

Where do Ixodes ticks live?

The eastern deer tick (Ixodes scapularis) is common in the midwestern and eastern parts of the United States but has been found as far south and west as Texas and South Dakota. The western deer tick (Ixodes pacificus) lives west of the Rocky Mountains, primarily along the California, Oregon, and Washington coasts.

Where are Ixodes ticks found?

The western blacklegged tick (Ixodes pacificus) is found along the Pacific coast of the United States, particularly northern California. Larvae and nymphs often feed on lizards, birds, and rodents, and adults more commonly feed on deer.

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