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What is the life expectancy with primary sclerosing cholangitis? After diagnosis, the average life expectancy ranges between 10 and 20 years. A liver transplant can give you a new lease on life. However, in 15% to 20% of cases, PSC may return after a liver transplant.
Even with specialized care, the typical individual with PSC will require liver transplant or die from complications between 9 and 20 years from diagnosis.
It can eventually lead to liver failure, repeated infections, and tumors of the bile duct or liver. A liver transplant is the only known cure for advanced primary sclerosing cholangitis, but the disease may recur in the transplanted liver in a small number of patients.
Patients are diagnosed between the ages of 30 and 40 years. The median age at the diagnosis of PSC was 41 years. PSC is more common in men (65% to 70%), and males have a 2-fold increased risk of developing PSC when compared to females.
CP Studies have suggested that the median transplant-free survival of patients with PSC ranges from 9.318 years; however, in a large population-based study on the epidemiology and natural history of PSC that we recently performed in The Netherlands, a median transplant-free survival of 21.3 years was found.
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Primary sclerosing cholangitis (PSC) tends to slowly and inexorably progress. The terminal phase involves decompensated cirrhosis, portal hypertension, ascites, and liver failure.

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