Atypical Antipsychotics 2025

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Typical antipsychotic drugs act on the dopaminergic system, blocking the type 2 (D2) receptors. Atypical antipsychotics have lower affinity and occupancy for the dopaminergic receptors, and a high degree of occupancy of the serotoninergic receptors 5-HT2A.
Atypical antipsychotics such as quetiapine, , olanzapine, and risperidone have been shown to be helpful in addressing a range of anxiety and depressive symptoms in individuals with schizophrenia and schizoaffective disorders, and have since been used in the treatment of a range of mood and anxiety disorders
Selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) SSRIs and SNRIs are often the first-line treatment for anxiety and major depressive disorder. Common SSRI brands are , Lexapro, Luvox, Paxil, and Zoloft.
Indeed, has been found to be effective in treating anxiety disorders through two open-label trials (Adson et al., 2005; Worthington et al., 2005).
The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin antagonists (SDAs), are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics)
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Atypical antipsychotics with D2 antagonism and partial agonism combined with 5-HT2A antagonism are more effective for treating mania, and these include , quetiapine, olanzapine, risperidone, and . Antipsychotics also have histamine, muscarinic (cholinergic), and -adrenergic antagonism.
The second generation antipsychotics are usually the first choice for the treatment of schizophrenia. Although they may not be officially approved for these other uses, they are sometimes used in the treatment of mood and anxiety disorders, such as bipolar, posttraumatic stress and obsessive-compulsive disorders.

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