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In Vitro Cytotoxicity Test Methods BRD Appendix G2 November 2006 NOTE: This Statement of Work shall

In Vitro Cytotoxicity Test Methods BRD Appendix G2 November 2006 NOTE: This Statement of Work shall -2025

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The document outlines the Statement of Work for the acquisition, preparation, solubility testing, and distribution of test chemicals for a multi-laboratory validation study focused on in vitro basal cytotoxicity testing. It details project objectives, guidelines, organizational structure, contractor responsibilities, and phases of the study. The primary goal is to evaluate the effectiveness of two specific in vitro assays (BALB/c 3T3 NRU and NHK NRU) in predicting acute toxicity levels while reducing animal use. The document emphasizes confidentiality regarding test chemicals and includes comprehensive procedures for handling and reporting throughout the study.

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