APPENDIX 11 Allergen immunotherapy administration form - ACAAI Member 2025

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Immunotherapy is usually recommended only if the person seems to be selectively sensitive to several allergens.
The immunotherapy goes directly into a vein. The immunotherapy comes in pills or capsules that you swallow. The immunotherapy comes in a cream that you rub onto your skin. This type of immunotherapy can be used for very early skin cancer.
Recommend using insulin syringe: if not available use 26/27G needles and graduated 1 mL syringes. Use middle third of posterior upper outer arm, pull the skin up and inject at 45 by deep subcutaneous route in the posterior aspect of the middle third of the arm. Gently draw back plunger before injecting.
An extract of a small amount of the allergen is injected into the skin of the arm. An injection may be given once a week (sometimes more often) for about seven months, after which injections can be administered every two weeks. Eventually, injections can be given every four weeks.
There are several formulations and treatment can be administered either via subcutaneous injections (SCIT) or via sublingual (SLIT) drops or tablets. For both methods, the principle is the same: the patient receives repeated amounts of the triggering allergen over time.
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