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Hyper- CVAD regimen for NHL and ALL Part B - williams medicine wisc

Hyper- CVAD regimen for NHL and ALL Part B - williams medicine wisc 2025

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The document outlines the Hyper-CVAD regimen for treating Non-Hodgkin Lymphoma (NHL) and Acute Lymphoblastic Leukemia (ALL), detailing the administration of Methotrexate and Cytarabine, along with supportive care measures such as hydration, prophylactic medications, anti-emetics, and CNS prophylaxis. It includes specific dosing instructions, monitoring requirements, and adjustments based on patient conditions. The treatment plan consists of alternating cycles of chemotherapy and emphasizes the importance of managing side effects and ensuring patient safety.

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What is the difference between CVAD and hyper-CVAD?

The term hyper refers to the hyperfractionated nature of the chemotherapy, which is given in smaller doses, more frequently, to minimize side effects. CVAD is the acronym of the drugs used in course A: cyclophosphamide, vincristine, doxorubicin (also known by its trade name, Adriamycin), and dexamethasone.

What drugs are in the hyper-CVAD regimen?

An abbreviation for a chemotherapy combination used to treat some types of acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). Hyper-CVAD includes the drugs cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride (Adriamycin), and dexamethasone.

What is the protocol for hyper-CVAD treatment?

The hyper CVAD regimen consists of a dose-intensive phase of therapy, consisting of eight cycles of alternating hyper CVAD and high-dose methotrexate/cytarabine followed by POMP maintenance (mercaptopurine 50 mg orally (PO) three times a day (TDS) on days 1 to 28, methotrexate 20 mg/m2 PO once a week, vincristine 2 mg

What is the hyper-CVAD regimen Part A?

This regimen consists of 8 alternating courses of Course A (cyclophosphamide, vincristine, doxorubicin, dexamethasone) and Course B (methotrexate, cytarabine), given every 21 to 28 days (A-B-A-B-A-B-A-B). Consider CNS prophylaxis with IT methotrexate and cytarabine.

What is the success rate of hyper-CVAD?

The Hyper-CVAD regimen has shown promising results for adult patients with acute lymphoblastic leukemia (ALL), as designed by the MD Anderson Cancer Center (MDACC). This treatment has resulted in a complete remission rate of 92% and a 5-year overall survival of 38%.

How long is the hyper-CVAD protocol?

You usually have a course of up to 8 cycles of treatment over a few months. Each cycle of hyper-CVAD usually lasts 21 days.

Hyper- CVAD regimen for NHL and ALL Part B - williams medicine wisc 2025

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