ICU Admission Orders - Severe Sepsis Bundle 2025

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The 3-hour recommendations, which must be carried out within 3 hours from the first time sepsis is suspected, are: 1) obtain a blood culture before antibiotics, 2) obtain a lactate level, 3) administer broad-spectrum antibiotics, and 4) administer 30 mL/kg of crystalloid fluid for hypotension (defined as a mean
The first part, named the severe sepsis 3-hour resuscitation bundle, contains all the therapeutic goals to be completed within 3 hours of the time of presentation with septic shock: (I) to measure lactate level; (II) to obtain blood cultures prior to administration of antibiotics; (III) to administer broad spectrum
Surviving Sepsis Campaign Hour-1 Bundle The hour-1 bundle encourages clinicians to act as quickly as possible to obtain blood cultures, administer broad spectrum antibiotics, start appropriate fluid resuscitation, measure lactate, and begin vasopressors if clinically indicated.
Sepsis Resuscitation Bundle The resuscitation bundle is a combination of evidence-based objectives that must be completed within 6 h for patients presenting with severe sepsis, septic shock, and/or lactate 4 mmol/L (36 mg/dL).
SSC Hour-1 Bundle of Care Elements: Measure lactate level* Obtain blood cultures before administering antibiotics. Administer broad-spectrum antibiotics. Begin rapid administration of 30mL/kg crystalloid for hypotension or lactate level 4 mmol/L.
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Sepsis covers a wide range of conditions which usually do not require admission to the intensive care unit (ICU) unless it becomes severe. When this occurs patients will often need ICU and broadly account for about 30% of admissions ing to the patient population.
The SSC protocol recommends early management of sepsis and septic shock as a one-hour bundle. Fluid resuscitation, which is initiated immediately and started within the first hour of sepsis and septic shock presentation, included obtaining serum lactate levels, performing hemoculture prior to empirical intravenous
Empiric antibiotic therapy is targeted at the suspected organism(s) and site(s) of infection and preferably administered within the first hour. If multiple antibiotics are administered, beta-lactam antibiotics should be prioritized [27].

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