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Protein knot server detection of knots in protein structures - dash harvard

Protein knot server detection of knots in protein structures - dash harvard 2025

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The document presents the Protein Knot Server, a web-based tool designed to detect knots in protein structures. It allows users to submit protein data bank (PDB) IDs or upload 3D protein structures in PDB or mmCIF format for analysis. The server utilizes the Alexander polynomial for knot detection and provides results including the knot's location, type, and interactive visualizations. The article discusses the significance of knots in proteins, their implications for folding and evolution, and highlights the challenges in identifying them using traditional methods.

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