Viral Membrane Fusion - dash harvard 2025

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Many viruses are surrounded by a continuous bilayer membrane studded with viral proteins. Its purpose is to protect the genome-containing virus nucleocapsid from damage, and to facilitate entry of the nucleocapsid into a host cell.
Beta-propiolactone (BPL) chemically inactivates enveloped viruses. BPL treatment was found to inhibit viral membrane fusion in a dose dependent manner. BPL modifies influenza virus proteins and clearly affects their functions.
Once a virus gets into a hosts body, it travels along the surfaces of cells until its proteins begin to bind with receptors on the cells. The virus and the cells then fuse, allowing the DNA or RNA inside the virus to enter the cells, where it begins to reproduce.
Entry via membrane fusion Viruses that enter a cell in this manner included , KSHV and simplex virus. In SARS-CoV-2 and similar viruses, entry occurs through membrane fusion mediated by the spike protein, either at the cell surface or in vesicles.
Membrane fusion is defined as the process where two membranes, such as the viral envelope and a host cell membrane, merge together, allowing the release of viral contents into the target cell.

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Class III fusion proteins are embedded in viral envelope with the principal function of catalyzing fusion of viral and cellular membranes, an event that is essential for infection to occur. In addition, they have been implicated in processes such as attachment to target cells and viral maturation.
Membrane fusion is an essential step when enveloped viruses enter cells. Lipid bilayer fusion requires catalysis to overcome a high kinetic barrier; viral fusion proteins are the agents that fulfill this catalytic function.
Membrane fusion, one of the most fundamental processes in life, occurs when two separate lipid membranes merge into a single continuous bilayer. Fusion reactions share common features, but are catalyzed by diverse proteins.

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