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NOVEL APPLICATIONS OF 2D AND 3D DEFORMABLE - sdsu-dspace calstate

NOVEL APPLICATIONS OF 2D AND 3D DEFORMABLE - sdsu-dspace calstate 2025

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The thesis explores novel applications of 2D and 3D deformable registration techniques in image-guided radiation therapy (IGRT), focusing on improving precision in tumor localization during treatment. It discusses the integration of cone-beam CT (CBCT) with simulated 4DCT images to correct for non-linear misalignments caused by respiratory motion, enhancing real-time tracking of lung tumors. The work evaluates various methods, including GPU-implemented deformable image registration (DIR) and principal component analysis (PCA), to optimize treatment planning and reduce toxicity to surrounding organs while increasing target dose coverage.

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