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I always get a few comments about whether these are food safe and my answer is as follows Black, red and yellow iron oxides are already used in many of the foods we eat, theyre used as colourants in confectionary, ice-cream cones and many more products that are safe to eat.
Furthermore, human epidemiological evidence from a number of studies suggests that iron oxide is not a human carcinogen, and therefore, based upon the complete weight of evidence, we conclude that bulk iron oxides are not human carcinogens.
Cooking utensils and cutlery are only safe if they are made out of materials that are not poisonous to humans. Neither elemental iron nor any of the iron oxides are poisonous to humans.
Another example, this time still approved for use in the European Union (EU), is the iron based additive E172, which is widely used as a natural colouring agent offering yellow, brown, red, or even black colour to food, drink, supplements, medicine, or cosmetics.
The iron oxide nanoparticles passed the gastrointestinal passage without dissolution and reached the intestine in the form of particles. Minor uptake was seen into Caco-2 cells but almost no transport to the basolateral site was detected for any of the tested particles.
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E172 is used as a natural colouring agent in food and drink products. The common names for E172 include certain iron oxides and iron hydroxides. E172 is a red/brown colouring that is available in three forms: E172(i) - black iron oxide, E172(ii) - red iron oxide, and.
Voss et al. investigated different engineered iron oxide nanoparticles, with all of them showing no acute toxicity on intestinal and hepatic cells, measured by various endpoints such as cell viability, oxidative stress or mitochondrial membrane potential (Voss et al., 2021).

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