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In the hippocampus, pyramidal cells in CA1 and the subiculum process sensory and motor cues to form a cognitive map encoding spatial, contextual, and emotional information, which they transmit throughout the brain.
The main subcortical limbic brain regions implicated in depression are the amygdala, hippocampus, and the dorsomedial thalamus. Both structural and functional abnormalities in these areas have been found in depression.
The CA1 region plays a role in input integration, and the subiculum contributes to memory retrieval (Small, Schobel, Buxton, Witter, Barnes, 2011). In addition to its role in learning and memory, the hippocampal formation has been implicated in other functions.
Long-term depression (LTD) is a lasting decrease in synaptic effectiveness that follows some types of electrical stimulation in the hippocampus.
In conclusion, the present experiments demonstrate that both hippocampal areas CA1 and CA3 contribute to the context dependence of extinguished fear. CA1 and CA3 are both required for contextual encoding of extinction, whereas area CA1 is essential for context-dependent retrieval.
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Two distinct forms of long-term depression (LTD), one dependent on the activation of NMDA receptors (NMDARs) and the other dependent on the activation of metabotropic glutamate receptors (mGluRs), are shown to coexist in CA1 hippocampal pyramidal cells of juvenile (1135 day-old) rats.

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