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The organic matrix of bone is composed of collagen and non-collagenous organic materials. Collagen comprises about 90% of the organic bone matrix. Type I collagen is the most abundant form of intrinsic collagen found in the bone that is secreted by osteoblasts.
Bone collagen. Most of the organic fraction of bone is collagen. In vivo bone collagen makes up approximately 2536% of the volume of bone material (Collins et al., 2002; Posner, 1969; Trueman et al., 2008).
It consists of two types of material: organic and inorganic. The inorganic portion makes about half of the weight of the bone. It mostly consists of calcium hydroxyapatite, but there are also significant amounts of bicarbonate, citrate, magnesium, potassium, and sodium ions.
Organic part of bone is a protein Ossein and Collagen fibres. Inorganic part of bone is mainly Calcium Phosphate.
The main inorganic components of the ECM are calcium-deficient apatite and trace elements. By contrast, the organic ECM is significantly more complex consists mainly of collagen type I (90%), and noncollagenous proteins (10%).
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As described above, by volume, bone consists of 40% inorganic component (hydroxyapatite), 25% water and 35% organic component (proteins) [1,2,12]. 90% of the organic component are collagen type I and the remaining 10% noncollagenous proteins.

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