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Method for site-specific integration of nucleic acids - Google Books

Method for site-specific integration of nucleic acids - Google Books 2025

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The document US005916804A describes a patent for a method of site-specific integration of nucleic acids using chimeric proteins. These proteins consist of a DNA-binding domain that attaches to target nucleic acids and an integrase domain that facilitates the integration of donor nucleic acids into these targets. The invention aims to improve gene therapy techniques by allowing precise control over where genetic material is integrated, thereby reducing risks associated with random insertion in the host genome.

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Is nucleic acids research peer-reviewed?

Nucleic Acids Research is a peer-reviewed fully open access journal publishing 24 issues per year online. All papers published in the Journal are made freely available online under open access publishing agreements, with applicable charges.

What are the research tools for nucleic acids?

These include PCR, RT PCR, sequencing and blotting. There are also techniques such as EMSA, footprinting, ChIP and probing that detect inter-molecular interactions of nucleic acids. Research in nucleic acids involves the isolation and characterization of DNA and RNA molecules from various cells, tissues, and organisms.

What are the methods of detection of nucleic acids?

There are several experimental techniques to detect and quantify nucleic acids in your sample. These include PCR, RT PCR, sequencing and blotting. There are also techniques such as EMSA, footprinting, ChIP and probing that detect inter-molecular interactions of nucleic acids.

What are the experimental methods to study protein nucleic acid interactions?

High-resolution structural approaches. The high-resolution methods for studying the structure of biological molecules at an atomic level, namely X-ray crystallography (XRC), nuclear magnetic resonance (NMR), and cryogenic electron microscopy (cryo-EM), can all be applied for the study of nucleic acidprotein complexes.

What is a nucleic acid in simple terms?

What are nucleic acids? Nucleic acids are naturally occurring chemical compounds that serve as the primary information-carrying molecules in cells. They play an especially important role in directing protein synthesis. The two main classes of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).

What is a nucleic acid journal?

Journal of Nucleic Acids is an open access journal publishing original research articles as well as review articles covering all structural, chemical, and functional aspects of DNA and RNA research.

What is nucleic acid research?

Nucleic Acids Research is an open-access peer-reviewed scientific journal published since 1974 by the Oxford University Press. The journal covers research on nucleic acids, such as DNA and RNA, and related work. According to the Journal Citation Reports, the journals 2021 impact factor is 19.160.

What are the methods for labeling nucleic acids?

Nucleic acid probes can be labeled with radioisotopes or nonisotopic labels for use in hybridization techniques. Common labeling methods include radioactive labeling with 32P or 3H, or nonisotopic labeling with biotin, digoxigenin, or fluorescein.