Phs 398 cover page supplement 2025

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Who we are. The Commissioned Corps of the U.S. Public Health Service, or USPHS Commissioned Corps, works on the front lines of public health. Our medical, health and engineering professionals fight disease, conduct research, and care for patients in underserved communities across the nation and throughout the world.
The Public Health Service Policy on Humane Care and Use of Laboratory Animals (PHS Policy) provides the regulatory framework for the use of live, vertebrate animals in any activity supported or conducted by the PHS agencies and U.S. Department of Health and Human Services components, or with entities which have an MOU
The PHS Policy, frequently referred to as the NIH Policy, requires each institution receiving PHS funds for research involving animals to submit detailed information regarding the institutions program for the care and use of animals (including farm animals, mice, and rats) to the Office of Laboratory Animal Welfare (
The PHS policy applies to all live vertebrate animals used in teaching, research and testing. The Guide describes the elements of acceptable institutional policies and veterinary care programs as well as specific physical requirements for the animal facility.
The PHS Policy and the U.S. Department of Agriculture (USDA) Animal Welfare Regulations (2) are the two principal federal documents setting forth requirements for animal care and use by institutions that use animals in research, testing, and education.
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The PHS 398 Research Plan form is used only for research, multi-project, and SBIR/STTR applications. This form includes fields to upload several attachments, including the Specific Aims and Research Strategy.

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