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To transfer a C-II controlled substance, like sodium pentobarbital, between laboratories, a DEA Form 222 order form is required. The receiving party must have a DEA Form 222. One laboratory is the supplier, acting like a pharmacy.
DEA form 224 must be filled by those dispensing controlled substances like a pharmacy and practitioners storing controlled substances for prescribing and distributing. The form is divided into 8 sections.
Electronic Schedule II Drug Ordering (e222)
Under 21 CFR 1305.03, the completion of DEA Form 222 is required for each distribution of a schedule I or II controlled substance.
The prescription must be transferred in its electronic form and may not be converted to another form ( e.g., paper, facsimile) for transmission. The information required to be on a controlled substance prescription pursuant to 21 CFR part 1306 must be unaltered during the transmission.

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Under the Controlled Substances Act (CSA), any practitioner prescribing, dispensing or administering CDS must have a valid DEA number. However, a DEA Number is not needed if the provider only prescribes Non-Controlled Substance.
DEA Form 222s are only used to transfer or order Schedule II controlled substances. Orders for Schedule II agents will not be accepted without a Form 222. Each book of DEA Official Order Forms consists of seven sets of forms.
This form is for new applicants. Any person who does not currently possess a DEA registration to conduct business with controlled substances in the following categories may access the application form.

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