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What happens if TB solution is not refrigerated?

Results: Most test situations didnt affect the biological activity of the tuberculin PPDs and only very long and extreme incubations (several days at 100 C) compromised the potency. Conclusions: Tuberculin PPD is very stable and can be stored or transported for long periods without refrigeration.

Does PPD have to be refrigerated?

Storage precautions for PPD antigen: a. Date each PPD vial when opened and discard PPD vials 30 days after opening. b. Keep PPD vials refrigerated at all times or in a cooler with ice packs.

How long is PPD solution good for once drawn up?

A vial of TUBERSOL which has been entered and in use for 30 days should be discarded.

How long is PPD stable at room temp?

It was found that the PPD solutions of all 3 strengths, 1, 5 and 250 TU per dose, were stable for at least 3 years at 4 degrees C and for 2 years at room temperature (24 degrees C). Even at 37 degrees C the solutions of all 3 strengths were stable for at least 1 year.

What is the mechanism of action of tuberculin?

Tuberculin PPD most likely interacts with toll-like receptor 2 expressed on APCs that initiates an inflammatory response. Subsequent restimulation of these sensitized lymphocytes with the same or a similar antigen, such as the intradermal injection of tuberculin PPD, evokes a local reaction mediated by these cells.

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What is the shelf life of tuberculin PPD?

36 months. A vial containing any unused product 30 days after the first dose is withdrawn should be discarded since oxidation and degradation may reduce the potency. Tubersol should be stored between 2 and 8C (35-48F).

What is tuberculin purified protein derivative PPD?

TUBERSOL Tuberculin Purified Protein Derivative (Mantoux), is indicated to aid diagnosis of tuberculosis infection (TB) in persons at increased risk of developing active disease.

How does Tubersol work?

Uses for Tubersol Tuberculin skin test is done by injecting tuberculin PPD into the surface layer of the skin. If the test is positive, a reaction will be seen at and around the place of injection or puncture. If the test is given using an injection, this reaction is usually a hard, raised area with clear margins.

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