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Here are the biggest PBMs by 2022 market share, ing to Drug Channels: CVS Health / Caremark: 33 percent. Cigna / Evernorth / Express Scripts: 24 percent. UnitedHealth / OptumRx: 22 percent. Humana Pharmacy Solutions: 8 percent. Prime Therapeutics / Magellan Rx: 5 percent. MedImpact Healthcare Systems: 4 percent.
The PBM provides 5 key functions: formulary design, utilization management, price negotiation, pharmacy network formation, and mail order pharmacy services. Criticism of the PBM industry centers around the lack of competition, pricing, agency problems, and lack of transparency.
By almost any measure, the pharmacy benefit management (PBM) business is one dominated by the major players. In 2021, CVS Caremark led the industry, controlling 34% of total adjusted claims, followed by Express Scripts (25%) and Optum Rx (21%).
For 2024, the three largest pharmacy benefit managers (PBMs)Caremark (CVS Health), Express Scripts (Cigna), and OptumRx (United Health Group)have again each excluded 600 or more drugs from their standard formularies.
To understand how three PBMs (Express Scripts, CVS Caremark, and Optum Rx) came to command such a massive chunk of a huge market, we need to look back at the origin of the industry.
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How big is the PBM industry? There are around 70 PBMs in the U.S. Through mergers, three of them CVS Caremark, Optum Rx, and Express Scripts have come to control 80% of the prescription drug market, and each brings in tens of billions of dollars in revenue annually.
Introduced in Senate (01/26/2023) This bill generally prohibits pharmacy benefit managers (PBMs) from engaging in certain practices when managing the prescription drug benefits under a health insurance plan, including charging the plan a different amount than the PBM reimburses the pharmacy.
The largest insurers (including Aetna, Cigna, Elevance, Humana, United Healthcare, and many non-profit Blue Cross Blue Shield plans) generally own PBMs or are part of companies that own PBMs.

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