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These therapies include reassurance, lifestyle modification, psychotherapy, dietary interventions, medical food, acupuncture, or electrical stimulation and modulation.
Non-pharmacological therapies (non-medication treatments): Referring to therapies that do not involve drugs. Non-opioid pharmacological treatments (medication treatments): Referring to non-opioid pain medications.
Non-pharmacological interventions (NPI) are any non-chemical intervention (theoretically supported) performed on and benefitting the patient. NPI have been employed as medical interventions (predating modern pharmacology), and are intended to improve quality of life, slow down deterioration or relieve pain.
Pharmacologic treatment: Non-opioid medications including acetaminophen, anticonvulsants, antidepressants, glucocorticosteroids, muscle relaxants and antispasmodics and non-steroid anti-inflammatory drugs.
A non-pharmaceutical intervention or non-pharmacological intervention (NPI) is any type of health intervention which is not primarily based on medication. Some examples include exercise, sleep improvement, or dietary habits.

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Non-pharmacological pain management is the management of pain without medications. This method utilizes ways to alter thoughts and focus concentration to better manage and reduce pain.
Comfort therapy may involve the following: Companionship. Exercise. Heat/cold application. Lotions/massage therapy. Meditation. Music, art, or drama therapy. Pastoral counseling. Positioning.
Some measures that can reduce pain intensity and improve the patient quality of life such as massage, positioning, hot and cold treatment, transcutaneous electrical nerve stimulation (TENS), acupuncture and progressive muscle relaxation.

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